Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences.
نویسندگان
چکیده
منابع مشابه
Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences
Highly purified populations of C57BL/6 (B6) L3T4+ and Lyt-2+ T cell subsets were compared for their capacity to exert alloreactivity to class I vs. class II H-2 differences in vivo. B6 Lyt-2+ cells responded strongly to the class I different mutant, bm1, as manifested by DNA synthesis in the spleen of irradiated mice followed by entry of blast cells into thoracic duct lymph, induction of spleno...
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In light of the widely accepted view that Ia-restricted L3T4+ T helper cells play a decisive role in controlling the differentiation of Lyt-2+ cells, experiments were designed to examine whether Lyt-2+ cells can respond to antigen in the absence of L3T4+ cells. The results showed that highly purified Lyt-2+ cells gave high primary mixed lymphocyte reactions (MLR) to various class I differences,...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1986
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.163.4.998